Chloramphenicol and phenobarbitone--a drug interaction.
نویسندگان
چکیده
Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.
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decline in chloramphenicol blood levels despite sustained IV treatment in high dosage. This decrease is probably explained by the induction of hepatic microsomal enzymes by phenobarbitone. Increased glucuronidation of chloramphenicol and a consequent decrease in therapeutic activity have been demonstrated in rats pretreated with phenobarbitone (Bella et al., 1968). The conventional chlorampheni...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 54 7 شماره
صفحات -
تاریخ انتشار 1979